Winston-Salem area bar, Single Brothers, concocted a bitters so tasty that it had to be bottled. Bitters were originally sipped as a health tonic in the 1800s and were eventually mingled with more powerful beverages to become the cocktails known and loved today. Thinking it only fitting that the Bitter Sisters Cocktail Mixer design be a throwback to a bygone era, local art director Shane Cranford chose a brown medicine bottle to package the mixer, along with over-embellishment, flourishes, elaborate type work and letterpress printing.