Original Formulary C.O. Bigelow Lotion Mentholus Soothing Topical Analgesic Lotion. Established in 1838, C.O. Bigelow is the oldest apothecary in America. Using only the finest quality ingredients and most effective active apothecary extracts most formulations have been selected right from C.O. Bigelow's historical formula books dating back to 1838. Others were inspired by traveling the world scouring for intriguing ingredients and indispensable remedies.